Glucocorticoid Receptor

Related Products

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor Related Products (259)
Antibodies (4)

By Effects:	Inhibitors (16) Agonists (163) Antagonists (20) Activators (10) Modulators (30)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-120012

Mizacorat	Modulator	99.71%
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC₅₀ of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

HY-B1893

Fluorometholone	Agonist	99.81%
Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye.

HY-B0248

Desonide	Inhibitor	99.64%
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on glucocorticoid receptors.

HY-B1183

Hydrocortisone acetate	Agonist	99.14%
Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids.

HY-13681

Methylprednisolone acetate	Agonist
Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid?hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.

HY-13571

Betamethasone dipropionate	Modulator	99.54%
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-B1197

Amcinonide	Agonist	99.63%
Amcinonide is a NO inhibitor that inhibits NO release from activated microglia with IC₅₀ of 3.38 nM. Amcinonide has glucocorticoid receptor affinity.

HY-14864

Mapracorat	Agonist	99.40%
Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

HY-B1618S

Corticosterone-d₈	Agonist	99.91%
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-111453

Velsecorat	Modulator	99.43%
AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC₅₀ of 0.9 nM.

HY-B0485

Fluocinonide	Agonist	99.63%
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.

HY-13683R

Mifepristone (Standard)	Antagonist	98.49%
Mifepristone (Standard) is the analytical standard of Mifepristone. This product is intended for research and analytical applications. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay.

HY-108243

AZD5423	Modulator	99.85%
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

HY-B1214

Prednisolone acetate	Agonist	99.83%
Prednisolone acetate (Prednisolone 21-acetate) is an adrenocortical hormone active molecule with various pharmacological effects such as anti-inflammatory, anti-allergic, and immune suppression.

HY-16722

Fosdagrocorat	Agonist	99.24%
Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist.

HY-136239

Beclomethasone 17-propionate	Agonist	99.76%
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.

HY-137882

Glucocorticoid receptor agonist-1 Ala-Ala-Mal	Agonist	99.94%
Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticosteroid, and an agonist of glucocorticoid receptor. Glucocorticoid receptor agonist-1 Ala-Ala-Mal can be conjugated with Adalimumab (HY-P9908) to prepare an ADC.

HY-117880

Exicorilant	Antagonist	98.28%
Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a K_i value of 7 nM. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia.

HY-147293

Nenocorilant	Inhibitor	99.72%
Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with K_i value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research.

HY-131974

Glucocorticoid receptor agonist-1	Agonist	99.80%
Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC₅₀ of 2.8 nM extracted from patent WO2017210471A1, compound 41.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor Related Products (259)

Antibodies (4)

Glucocorticoid Receptor Related Products (259):